The association between bisphenol a exposure and attention deficit hyperactivity disorder in children: a meta-analysis of observational studies

Abstract

Abstract Introduction The association between Bisphenol A (BPA) exposure and attention deficit hyperactivity disorder (ADHD) has been a controversial topic. Objective: To evaluate the connection between BPA exposure and ADHD. Content We search Scopus, Web of Science, and Medline databases until August 2022. The meta-analysis was performed by using the software Stata 12.0 to calculate the combined effect value Odds ratios (OR) and 95% confidence interval (95%CI). A total of 8 studies were included in this meta-analysis, including 5,710 children. Using the random effect model, it was found that compared with the lowest level of BPA exposure, the OR (95%CI) value of urine BPA exposure and ADHD in the highest level of BPA exposure was 1.76 (1.13–2.74). Summary and Outlook Based on the current meta-analysis results, BPA exposure may be a significant contributing factor to the development of ADHD in children.