Antibacterial activity of some chemical constituents from Trichilia prieuriana (Meliaceae)
Author:
Pagna Julio Issah Mawouma1, Mbekou Ines Michèle Kanko2, Tsamo Armelle Tontsa1, Mkounga Pierre1, Frese Marcel3, Stammler Hans-Georg4, Fekam Fabrice Boyom2, Lenta Bruno Ndjakou5, Sewald Norbert3, Nkengfack Augustin Ephrem1
Affiliation:
1. Department of Organic Chemistry , Faculty of Science, University of Yaoundé I , P.O. Box 812 , Yaoundé , Cameroon 2. Department of Biochemistry , Faculty of Science, The University of Yaoundé I , P.O. Box 812 Yaoundé , Cameroon 3. Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University , D-33501 Bielefeld , Germany 4. Inorganic and Structural Chemistry, Faculty of Chemistry, Bielefeld University , D-33501 Bielefeld , Germany 5. Department of Chemistry , Higher Teacher Training College, University of Yaoundé I , P.O. Box 47 , Yaoundé , Cameroon
Abstract
Abstract
The chemical study of hydroethanolic extracts from different parts of Trichilia prieuriana (Meliaceae) led to the isolation and identification of 22 compounds: 2β,3β,4β-trihydroxypregnan-16-one (1), prieurianin (2), flindissone (3), deoxyflindissone (4), picraquassin E (5), ursolic acid (6), 3β-acetoxy-11α-hydroxyurs-12-en (7), 3β-acetoxy-urs-12-en-11-one (8), 3β-acetoxy-β-amyrin (9), friedelin-3-ol (10), 3-oxo, friedelin (11), 3-oxo, fridelin-28-ol (12), oleanolic acid (13), hederagenin (14), mixture of stigmasterol (15), β-sitosterol (16), β-sitosterol-3-O-β-glucopyranoside (17) and stigmasterol-3-O-β-glucopyranoside (18), erythrodiol (19), scopoletin (20), 4-hydroxy-3,5-dimethoxybenzoic acid (21) and shikimic acid (22). The absolute configurations and crystal structures of compounds 1 and 2 are reported herein for the first time. Crude extracts, fractions and isolated compounds were evaluated for their antibacterial activities against nine bacterial strains. Crude extracts from the root wood of T. prieuriana exhibited good antibacterial potency with minimal inhibitory concentration (MIC) values ranging from 31.25 to 500 µg mL−1 on the test bacteria. The ethyl acetate fraction from root wood and n-hexane-ethyl acetate (3:1) fraction from leaves showed a moderate antibacterial activity with MIC value of 250 μg mL−1 on all test bacteria. Isolated compounds exhibited significant antibacterial activity with MIC values ranging from 4.09 to 71.8 µm. Compounds 3, 6 and 7 were the most active with a broad spectrum of activities.
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
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