Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions-Reference-Cited by-同舟云学术

Synthesis and characterization of capsaicin nanoparticles: An attempt to enhance its bioavailability and pharmacological actions

Published:2024-01-01 Issue:1 Volume:13 Page:
ISSN:2191-9550
Container-title:Green Processing and Synthesis
language:en
Short-container-title:

Author:

Sher Mujahid¹²,Hussain Ishtiaq¹³,Khan Farhat Ali⁴,Zahoor Muhammad⁵,Sher Wiaam Mujahid⁶,Khalil Muhammad Saqib⁷,Sulaiman Muhammad⁸,Ullah Riaz⁹,Naz Sumaira⁵,Ali Essam A.¹⁰

Affiliation:

1. Department of Pharmacy, Abbottabad University of Science and Technology , Abbottabad , Pakistan

2. Premiere institute of Health Management Sciences , Peshawar , KP , Pakistan

3. Department of Pharmaceutical Sciences, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology , Khanpur Road , Mang Haripur , Pakistan

4. Department of Pharmacy, Shaheed Benazir Bhutto University Sheringal , Dir Upper , Pakistan

5. Department of Biochemistry, University of Malakand , Chakdara, Lower Dir , Khyber Pakhtunkhwa , 18000 , Pakistan

6. Department of Health Sciences, Khyber Medical College Peshawar , Peshawar , Pakistan

7. Department of Allied Health Sciences, Sarhad University of Information Technology , Peshawar , Pakistan

8. Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University , Nanjing , China

9. Department of Pharmacognosy, College of Pharmacy, King Saud University , Riyadh , Saudi Arabia

10. Department of Pharmacy, College of Pharmacy, King Saud University , Riyadh , Saudi Arabia

Abstract

Abstract Herein, capsaicin nanoparticles (NPs) were prepared by two different methods, namely, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP). The nanoparticles of the necessary sizes were obtained after optimizing experimental parameters such as the solvent-to-anti-solvent ratio and stirring speed. They had spherical shapes and an average diameter of 171.29 ± 1.94 and 78.91 ± 0.54 nm when prepared using the EPN and APSP methods, respectively. Differential scanning calorimetry and an X-ray diffractometer showed that the capsaicin crystallinity decreased. FTIR results showed that the NPs were produced with their original configuration and did not result in the synthesis of any additional structures. The NP formulation had a desirable drug content. They surpassed the unprocessed drug in solubility and displayed the desired stability. Capsaicin NP cream showed many folds of enhanced analgesic, anti-inflammatory, and antimicrobial effects compared to unprocessed capsaicin.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/gps-2023-0206/pdf

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