Antibacterial wound dressing with hydrogel from chitosan and polyvinyl alcohol from the red cabbage extract loaded with silver nanoparticles

Author:

Kaliaperumal Kumaravel1,Subramanian Kumaran2,Thirunavukkarasu Rajasekar2,Varadharajan Ramesh Kumar3,Binsuwaidan Reem4,Alabdallah Nadiyah M.56,Alshammari Nawaf7,Saeed Mohd7,Anbarasu Krishnan8,Karunakaran Rohini91011

Affiliation:

1. Unit of Biomaterials Research, Department of Orthodontics, Saveetha Dental College, SIMATS, Saveetha University , Chennai , Tamilnadu , India

2. Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology , Chennai , Tamilnadu , India

3. Department of Biotechnology, Sathyabama Institute of Science and Technology , Chennai , Tamilnadu , India

4. Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University , P.O. Box 84428 , Riyadh 11671 , Saudi Arabia

5. Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University , P.O. Box 1982, 31441 , Dammam , Saudi Arabia

6. Department of Biology, Basic and Applied Scientific Research Centre, Imam Abdulrahman Bin Faisal University , P.O. Box 1982 , Dammam 31441 , Saudi Arabia

7. Department of Biology, College of Sciences, University of Hail , Hail 55476 , Saudi Arabia

8. Department of Bioinformatics, Saveetha School of Engineering, SIMATS , Chennai , Tamilnadu , India

9. Department of Biochemistry, Faculty of Medicine, AIMST University , Bedong , Malaysia

10. Department of Bioinformatics, Centre for Excellence for Biomaterials Science, AIMST University , Bedong , P.O. Box 08100 , Malaysia

11. Department of Computational Biology, Saveetha School of Engineering, SIMATS , Chennai , India

Abstract

Abstract The aim of the present study was the synthesis of hydrogel incorporated with chitosan blend with polyvinyl alcohol (PVA) from red cabbage Brassica oleracea and its application in wound healing and antibacterial activity. The chitosan/PVA hydrogel was synthesized by the combination of chitosan and PVA treated with acetic acid. The silver nanoparticles (AgNPs) were synthesized from the B. oleracea extract and its antibacterial efficacy was examined. The synthesized nanoparticles (NPs) were characterized using UV-spectroscopy and X-ray diffraction methods. The synthesized NPs were purified and combined with the hydrogel. This combined hydrogel and AgNP mixture was then subjected to Fourier transform infrared analysis, and the results were observed to conclude the effectiveness of the hydrogel. This hydrogel would differ in the part of dressing the wound, that is it can last on the wound for a longer period, thus reducing the pain and frequency of dressing and in turn naturally healing the wound in less time.

Publisher

Walter de Gruyter GmbH

Subject

Health, Toxicology and Mutagenesis,Industrial and Manufacturing Engineering,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Environmental Chemistry

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