Author:
Cern Ahuva,Michael-Gayego Ayelet,Bavli Yaelle,Koren Erez,Goldblum Amiram,Moses Allon E.,Xiong Yan Q.,Barenholz Yechezkel
Abstract
AbstractMupirocin is an antibiotic having a unique mode of action, not shared by any other therapeutically available antibiotic. However, due to its rapid elimination following injection and high protein binding, current therapeutic use is limited to topical administration. Computational methods have identified mupirocin as a good candidate for delivery via long-circulating nano-liposomes. Formulating mupirocin in such liposomes to form Nano-mupirocin protects the drug in the circulation, enabling therapeutic efficacy. This was demonstrated using two different animal models that served as a proof of concept: the mice
Subject
Physical and Theoretical Chemistry,Biomedical Engineering,Medicine (miscellaneous),Bioengineering
Cited by
12 articles.
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