Neuropeptide Y and measures of stress in a longitudinal study of women with the fibromyalgia syndrome

Author:

Karlsson Bo1ORCID,Nyberg Fred2ORCID,Svärdsudd Kurt1ORCID,Burell Gunilla1ORCID,Björkegren Karin1,Kristiansson Per1ORCID

Affiliation:

1. Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden

2. Department of Pharmaceutical Biosciences , Uppsala University , Uppsala , Sweden

Abstract

Abstract Objectives Neuropeptide Y is associated with stress in animal and human laboratory studies. However, data from clinical studies are scarce and no clinical longitudinal studies have been published. The aim of this clinical study was to assess the possible association between changes in the levels of pain, depression, and stress measures, on the one hand, and plasma neuropeptide Y levels, on the other. Methods Forty-four women with the fibromyalgia syndrome were exposed to a Cognitive Behavioral Therapy intervention. Levels of the plasma neuropeptide Y as well as pain, depression, and stress measures were obtained at the start and at the end of the intervention, and after a further six month follow-up. Based on these data, a before-and-after analysis was performed. Results Almost all measures of pain, depression, and stress improved during the study; specifically, variables measuring life control (coping), depression, and stress-related time urgency improved significantly. Moreover, during the same time period, the mean plasma neuropeptide Y level was reduced from 93.2 ± 38.8 fmol/mL before the Cognitive Behavioral Therapy to 75.6 ± 42.9 fmol/mL (p<0.001) at the end of the study. Conclusions After exposure to a Cognitive Behavioral Therapy intervention, levels of most of the pain, depression, and stress measures improved, half of them significantly, as did the levels of neuropeptide Y. This circumstance indicates a possible functional relationship between pain-depression-stress and neuropeptide Y.

Funder

Vetenskapsrådet

Stiftelsen Söderström Königska Sjukhemmet

Reumatologförbundet

Uppsala Universitet

Försäkringskassan Swedish Social Insurance Agency

51/04

vetenskapsrådetvr.se

Publisher

Walter de Gruyter GmbH

Subject

Anesthesiology and Pain Medicine,Neurology (clinical)

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