Affiliation:
1. Department of Public Health and Caring Sciences , Uppsala University , Uppsala , Sweden
2. Department of Pharmaceutical Biosciences , Uppsala University , Uppsala , Sweden
Abstract
Abstract
Objectives
Neuropeptide Y is associated with stress in animal and human laboratory studies. However, data from clinical studies are scarce and no clinical longitudinal studies have been published. The aim of this clinical study was to assess the possible association between changes in the levels of pain, depression, and stress measures, on the one hand, and plasma neuropeptide Y levels, on the other.
Methods
Forty-four women with the fibromyalgia syndrome were exposed to a Cognitive Behavioral Therapy intervention. Levels of the plasma neuropeptide Y as well as pain, depression, and stress measures were obtained at the start and at the end of the intervention, and after a further six month follow-up. Based on these data, a before-and-after analysis was performed.
Results
Almost all measures of pain, depression, and stress improved during the study; specifically, variables measuring life control (coping), depression, and stress-related time urgency improved significantly. Moreover, during the same time period, the mean plasma neuropeptide Y level was reduced from 93.2 ± 38.8 fmol/mL before the Cognitive Behavioral Therapy to 75.6 ± 42.9 fmol/mL (p<0.001) at the end of the study.
Conclusions
After exposure to a Cognitive Behavioral Therapy intervention, levels of most of the pain, depression, and stress measures improved, half of them significantly, as did the levels of neuropeptide Y. This circumstance indicates a possible functional relationship between pain-depression-stress and neuropeptide Y.
Funder
Vetenskapsrådet
Stiftelsen Söderström Königska Sjukhemmet
Reumatologförbundet
Uppsala Universitet
Försäkringskassan Swedish Social Insurance Agency
51/04
vetenskapsrådetvr.se
Subject
Anesthesiology and Pain Medicine,Neurology (clinical)
Cited by
1 articles.
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