Neuropathic pain after surgery – A clinical validation study and assessment of accuracy measures of the 5-item NeuPPS scale-Reference-Cited by-同舟云学术

Neuropathic pain after surgery – A clinical validation study and assessment of accuracy measures of the 5-item NeuPPS scale

Published:2024-01-01 Issue:1 Volume:24 Page:
ISSN:1877-8879
Container-title:Scandinavian Journal of Pain
language:en
Short-container-title:

Author:

Andersen Kenneth Geving¹²,Christensen Karl Bang³,Kehlet Henrik¹,Mejdahl Mathias Kvist⁴

Affiliation:

1. Section for Surgical Pathophysiology, 7621, Rigshospitalet, University of Copenhagen , Blegdamsvej 9, DK-2100 , Copenhagen , Denmark

2. Department of Anesthesiology, Hvidovre Hospital, University of Copenhagen , Copenhagen , Denmark

3. Section of Biostatistics, Department of Public Health, University of Copenhagen , Copenhagen , Denmark

4. Department of Breast Surgery, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark

Abstract

Abstract Objective The aim of this study was to validate the Neuropathic Pain for Post-Surgical Patients (NeuPPS) scale against clinically verified neuropathic pain (NP) by quantitative sensory testing (QST) as well as evaluation of other psychometric properties. The NeuPPS is a validated 5-item scale designed to evaluate NP in surgical populations. Methods Data from 537 women aged >18 years scheduled for primary breast cancer surgery enrolled in a previous study for assessing risk factors for persistent pain after breast cancer treatment were used. Exclusion criteria were any other breast surgery or relevant comorbidity. A total of 448 eligible questionnaires were available at 6 months and 455 at 12 months. At 12 months, 290 patients completed a clinical examination and QST. NeuPPS and PainDETECT were analyzed against patients with and without clinically verified NP. NP was assessed using a standardized QST protocol including a clinical assessment. Furthermore, the NeuPPS and PainDETECT scores were psychometrically tested with an item response theory method, the Rasch analysis, to assess construct validity. Primary outcomes were the diagnostic accuracy measures for the NeuPPS, and secondary measures were psychometric analyses of the NeuPPS after 6 and 12 months. PainDETECT was also compared to clinically verified NP as well as NeuPPS comparing the stability of the estimates. Results Comparing the NeuPPS scores with verified NP using a receiver operating characteristic curve, the NeuPPS had an area under the curve of 0.80. Using a cutoff of 1, the NeuPPS had a sensitivity of 88% and a specificity of 59%, and using a cutoff of 3, the values were 35 and 96%, respectively. Analysis of the PainDETECT indicated that the used cutoffs may be inappropriate in a surgical population. Conclusion The present study supports the validity of the NeuPPS as a screening tool for NP in a surgical population.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/sjpain-2023-0072/pdf

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