Structure and Activity of Insulin, XVl. Semisyntheses of Desheptapeptide-(B24—30)- up to Destripeptide-(B28—30)-Insulin with Lysine or Alanine in Place of Arginine in Position B22: Influence on the Three-Step-Increase of Activity in Positions B24—26 (Phe-Phe-Tyr)
Author:
Publisher
Walter de Gruyter GmbH
Subject
Biochemistry
Link
https://www.degruyter.com/document/doi/10.1515/bchm2.1978.359.2.945/pdf
Reference14 articles.
1. Structure and Activity of Insulin, XII. Further Studies on Biologically Active Synthetic Fragments of the B-Chain
2. Structure and Activity of Insulin, XIII. Specificity of the Arginine-Guanidino Group in Biologically Active Tetrapeptides of the Insulin Sequence B 22 - 25 (Arg-Gly-Phe-Phe)
3. Structure and Activity of Insulin, XV. Further Evidence for the Importance of Arginine Residue B 22 in the Activity of Insulin. Semisyntheses of Despentapeptide-(B 26 - 30)-Insulins Varied in B 22 Using Desnonapeptide-(B 22 - 30)-Insulin and Tetrapeptides
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1. Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26;Biochemistry and Biophysics Reports;2017-09
2. Diabetes mellitus caused by mutations in human insulin: analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics;Journal of Biomolecular Structure and Dynamics;2016-04-14
3. Aromatic Anchor at an Invariant Hormone-Receptor Interface;Journal of Biological Chemistry;2014-12
4. Receptor Binding Studies on A1-(2-Nitro-4-trimethylammoniophenyl)insulin;Hoppe-Seyler´s Zeitschrift für physiologische Chemie;1979-01
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