Über das Auftreten von Pterinen, Tryptophan und dessen Derivate in verschiedenen Organen der Mutante white von Drosophila melanogaster

Abstract

It was shown that the Malpighian tubules of the white-eyed mutant of Drosophila melanogaster have few fluorescent substances, as compared with the wild type. Apparently these Malpighian tubules are not able to take up and accumulate some pteridines, tryptophan and kynurenine. These substances, found in high amounts in meconia and feces, are excreted by the hind-gut. In the pattern of the fluorescent substances of the ovaries and eggs no differences could be found between the wild type and the mutant white. The high amount of isoxanthopterin in the Malpighian tubules of the white strain of Drosophila melanogaster (Inst. of Technology, Pasadena) is due to modifier genes. These genes could be eliminated by repeated back-crossing of the strain with flies of the wild type.