Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship-Reference-Cited by-同舟云学术

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship

Published:2005-01-01 Issue:3 Volume:43 Page:
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:
Short-container-title:

Author:

Dorado Pedro,Berecz Roland,Cáceres Macarena C.,González Idilio,Cobaleda Jesús,LLerena Adrián

Abstract

AbstractThe drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs. So far more than 50 different

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/CCLM.2005.046/pdf

Reference20 articles.

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2. de la QTc interval and CYP genotypes and risperidone plasma concentrations;LLerena;J Psychopharmacol,2004

3. Direct determination of debrisoquine and - hydroxydebrisoquine using a high - performance liquid chromatographic switching technique;Decolin;J Chromatogr,1987

4. Comparison of gas chromatographic and high - performance liquid chromatographic assays for the determination of debrisoquine and its - hydroxy metabolite in human fluids;Chan;J Chromatogr,1988

5. Rapid liquid chromatographic determination of debrisoquine and its hydroxy metabolite in human urine to define hydroxylation phenotypes;Duche;J Chromatogr,1987

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