Author:
Herrmann Wolfgang,Obeid Rima
Abstract
AbstractThe role of hyperhomocysteinemia (HHcy) as a risk marker for cardiovascular diseases in renal patients is a matter of controversy. The remethylation of homocysteine (Hcy) to methionine in the kidneys is of great importance for Hcy clearance. Hcy remethylation is markedly decreased in patients on hemodialysis, but transsulfuration remains mostly unaffected. Markedly increased concentrations of methylmalonic acid (MMA), as a metabolic marker of vitamin B
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
Reference71 articles.
1. Homocysteine and cardiovascular disease : evidence on causality from a meta - analysis;Wald;Br Med J,2002
2. Homocysteine metabolism;Selhub;Annu Rev Nutr,1999
3. Adenosine binding sites at adenosylhomocysteine hydrolase are controlled by the NAD + / NADH ratio of the enzyme;Kloor;Biochem Pharmacol,2003
4. Quantitation of total homocysteine , total cysteine , and methionine in normal serum and urine using capillary gas chromatography - mass spectrometry;Stabler;Anal Biochem,1987
5. Metabolic consequences of hyperhomocysteinemia in uremia;Perna;Am J Kidney Dis,2001
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