CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data-Reference-Cited by-同舟云学术

CAT PETR: a graphical user interface for differential analysis of phosphorylation and expression data

Published:2023-01-01 Issue:1 Volume:22 Page:
ISSN:2194-6302
Container-title:Statistical Applications in Genetics and Molecular Biology
language:en
Short-container-title:

Author:

Flanagan Keegan¹^ORCID,Pelech Steven²,Av-Gay Yossef³,Dao Duc Khanh⁴^ORCID

Affiliation:

1. Department of Mathematics and Department of Microbiology and Immunology , University of British Columbia , Vancouver , Canada

2. Department of Medicine , Kinexus Bioinformatics Corporation and University of British Columbia , Vancouver , Canada

3. Department of Microbiology and Immunology , University of British Columbia , Vancouver , Canada

4. Department of Mathematics , University of British Columbia , Vancouver , Canada

Abstract

Abstract Antibody microarray data provides a powerful and high-throughput tool to monitor global changes in cellular response to perturbation or genetic manipulation. However, while collecting such data has become increasingly accessible, a lack of specific computational tools has made their analysis limited. Here we present CAT PETR, a user friendly web application for the differential analysis of expression and phosphorylation data collected via antibody microarrays. Our application addresses the limitations of other GUI based tools by providing various data input options and visualizations. To illustrate its capabilities on real data, we show that CAT PETR both replicates previous findings, and reveals additional insights, using its advanced visualization and statistical options.

Publisher

Walter de Gruyter GmbH

Subject

Computational Mathematics,Genetics,Molecular Biology,Statistics and Probability

Link

https://www.degruyter.com/document/doi/10.1515/sagmb-2023-0017/pdf

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