Multivariate association between single-nucleotide polymorphisms in Alzgene linkage regions and structural changes in the brain: discovery, refinement and validation-Reference-Cited by-同舟云学术

Multivariate association between single-nucleotide polymorphisms in Alzgene linkage regions and structural changes in the brain: discovery, refinement and validation

Published:2017-11-27 Issue:5-6 Volume:16 Page:
ISSN:1544-6115
Container-title:Statistical Applications in Genetics and Molecular Biology
language:
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Author:

Szefer Elena,Lu Donghuan,Nathoo Farouk,Beg Mirza Faisal,Graham Jinko

Abstract

AbstractUsing publicly-available data from the Alzheimer’s Disease Neuroimaging Initiative, we investigate the joint association between single-nucleotide polymorphisms (SNPs) in previously established linkage regions for Alzheimer’s disease (AD) and rates of decline in brain structure. In an initial, discovery stage of analysis, we applied a weighted

Publisher

Walter de Gruyter GmbH

Subject

Computational Mathematics,Genetics,Molecular Biology,Statistics and Probability

Link

https://www.degruyter.com/document/doi/10.1515/sagmb-2016-0077/pdf

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