Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities-Reference-Cited by-同舟云学术

Novel ruthenium(ii) N-heterocyclic carbene complexes: Synthesis, characterization, and evaluation of their biological activities

Published:2023-01-01 Issue:1 Volume:46 Page:
ISSN:2191-0219
Container-title:Main Group Metal Chemistry
language:en
Short-container-title:

Author:

Jawhari Ahmed Hussain¹,Amri Nasser¹,Mukhrish Yousef E.¹,Gatri Rafik²,Özdemir Ismail³⁴,Gürbüz Nevin³⁴,Mansour Lamjed⁵,Koko Waleed S.⁶,Hamdi Naceur⁷

Affiliation:

1. Department of Chemistry, Faculty of Science, Jazan University , P.O. Box 2097 , Jazan 45142 , Saudi Arabia

2. Laboratoire de Synthèse Organique Sélective et Hétérocyclique Évaluation Biologique LR17ES01 Faculté des Sciences de Tunis Faculté des Sciences de Tunis Campus Universitaire, Université de Tunis El Manar , 1092 Tunis , Tunisia

3. İnönü University, Catalysis Research and Application Center , 44280 Malatya , Turkey

4. Department of Chemistry, Faculty of Science and Art, İnönü University , 44280 Malatya , Turkey

5. Zoology Department, College of Science, King Saud University, Saudi Arabia , P.O. Box 2455 , Riyadh 11451 , Saudi Arabia

6. Department of Science Laboratories, College of Science and Arts, Qassim University , Ar Rass 51921 , Saudi Arabia

7. Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage , Hammam-Lif , Tunisia

Abstract

Abstract A series of ruthenium(ii) complexes with N-heterocyclic carbene (NHC) ligands of the general type (arene)(NHC)Ru(ii)X2 (where X = halide) (3a–3d) were synthesized and characterized in order to compare their antibacterial activities with benzimidazolium salts 2. Our comparison revealed that ruthenium(ii) NHC complexes 3 were more active than benzimidazolium salts 2. Furthermore, the two complexes 3b and 3d had a potent inhibitory effect against acetylcholinesterase with an IC50 of 4.52 and 4.04 g·mL−1 and against tyrosinase with an IC50 of 20.77 and 25.84 g·mL−1, respectively. In addition, screening of benzimidazolium salts (2a–2d) and their ruthenium(ii) complexes (3a–3d) against colon carcinoma cell lines (HCT-116) and hepatocellular carcinoma cell lines (HepG-2) were studied. The obtained results revealed that complex 3a is the most active against vinblastines.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,Metals and Alloys,Condensed Matter Physics,General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/mgmc-2023-0008/pdf

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