Affiliation:
1. School of Materials Science and Engineering, East China Jiaotong University , Nanchang , Jiangxi, 330013 , China
Abstract
Abstract
In this study, metal–organic nanofibers (MONFs) and reduced graphite oxide (rGO) nanocomposite were used to modify the surface of glassy carbon electrode, and the electrochemical sensor was applied to the differential pulse voltammetry determination of hypoxanthine, the oxidation intermediate of human purine degradation metabolism. The preparation of MONFs/rGO nanocomposite is simple, efficient, and environmentally friendly. The morphology and structure of MONFs/rGO nanocomposite were characterized by field emission scanning electron microscopy and X-ray diffraction. The results show that the improved sensor has a significant increase in current density, with linear ranges of 0.1–10 and 20–100 μM. Detection limit 0.01 μM (S/N = 3). Under the optimized conditions, the improved sensor shows very good stability, selectivity, and improved accuracy.
Reference49 articles.
1. Yang ZH, Cai XP, Lu BY, Xu X, Li H. Voltammetric response of [Co(phen)3]3+ and gold nanoparticles/multi-walled carbon nanotubes to two C-6 substituted purines. J Electroanalyt Chem. 2015;743:78–85.
2. Liu BB, Wang XY, Liu HQ, Zhai YY, Li L, Wen HR. 2D MOF with electrochemical exfoliated graphene for nonenzymatic glucose sensing: central metal sites and oxidation potentials. Anal Chim Acta. 2020;1122:9–19.
3. Zhao ZX, Yang X, Wei J, Chen XM. Colorimetric determination of hypoxanthine in fish based on the enzyme mimetic activity of copper nanoclusters. Food Sci (China). 2021;42(20):246–51.
4. Ma CC, Zhang JK, Lu Z, Han JX, Xing RR, Hao JX. A review of methods for freshness detection of aquatic products. Food Sci (China). 2020;41(19):334–42.
5. Liao LC, Xing Y, Xiong XL, Gan L, Hu L, Zhao F, et al. An electrochemical biosensor for hypoxanthine detection in vitreous humor: a potential tool for estimating the post-mortem interval in forensic cases. Microchem J. 2020;155:104760–6.