Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products-Reference-Cited by-同舟云学术

Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Published:2022-01-01 Issue:1 Volume:28 Page:11-17
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:en
Short-container-title:

Author:

Bellili Soumaya¹,Coltman Nicholas J.²,Hodges Nikolas J.²,Allouche Fatma¹

Affiliation:

1. Department of Chemistry, University of Sfax, Laboratory of Medicinal and Environmental Chemistry , 3018 Sfax , Tunisia

2. The School of Biosciences, The University of Birmingham, Edgbaston , Birmingham , B15 2TT , United Kingdom

Abstract

Abstract This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 precursors. The action of chlorosulfonyl isocyanate (CSI) with aminopyrazolo[3,4-d]pyrimidines 2 was found to produce triazolopyrimidinones 5 . The MTT test that quantifies mitochondrial reductive function demonstrated that in both cell lines tested (PE/CA-PJ41 and HePG2 cells), the benzamide compounds 4 are moderately toxic with PE/CA-PJ41 cells and more sensitive than HePG2 cells.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2022-0001/pdf

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