A green method for the preparation of phoxim based on high-boiling nitrite-Reference-Cited by-同舟云学术

A green method for the preparation of phoxim based on high-boiling nitrite

Published:2021-01-01 Issue:1 Volume:10 Page:309-313
ISSN:2191-9550
Container-title:Green Processing and Synthesis
language:en
Short-container-title:

Author:

Dong Changzan¹,Qiao Jinwen²,Zhu Hongwei²,Qian Guang¹²,Zhu Jie²,He Yupeng¹

Affiliation:

1. School of Petrochemical Engineering, Liaoning Shihua University , Fu Shun , 113001 , China

2. School of Biological and chemical Engineering, Jiaxing University , Jiaxing , 314001 , China

Abstract

Abstract Phoxim is a significant insecticide, and its current synthesis method has some shortcomings such as the high risk of explosion and the trans structure (main impurity) is hard to control. Our work solved the above disadvantages by introducing macromolecular alcohol (benzyl alcohol, etc.) as the starting material and optimizing the intermediate reaction conditions. Compared with the current synthesis route, the synthetic method has the following advantages: (1) intermediate benzyl nitrite has a high boiling point and strong safety; (2) intermediate α-cyanobenzaldehyde oxime sodium are almost (≥99%) cis structure, and no further refinement was required, which greatly reduced the amount of waste water produced; and (3) The high yield of phoxim was maintained at 72.9%.

Publisher

Walter de Gruyter GmbH

Subject

Health, Toxicology and Mutagenesis,Industrial and Manufacturing Engineering,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Environmental Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/gps-2021-0017/pdf

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