Fused thia-heterocycles via isothiocyanates. Part I. Facile synthesis of some new 1-benzothiopyran- 4-one derivatives
Author:
Barhoumi Lina M.1, El-Abadelah Mustafa M.1, Sabri Salim S.1, Voelter Wolfgang2
Affiliation:
1. Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan 2. Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler Straße 4, 72076 Tübingen, Germany
Abstract
Abstract
A selected set of new 4H-benzothiopyran-4-one derivatives 6a–h has been prepared by a one-pot reaction involving deprotonated methyl 3-oxo-3(2′,4′,5′-trichlorophenyl)propanoate 5 and the appropriate aryl or alkyl isothiocyanate. 2,4,5-Trichloroacetophenone 4, required for the synthesis of 5, is successfully prepared by Friedel–Craft’s acetylation of 1,2,4-trichlorobenzene in 82% yield. The structures of the new compounds 5 and 6a–h are based on microanalytical and spectral (NMR, MS(EI), and HRMS) data.
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
Reference33 articles.
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