Synthesis and biological evaluation of 1,3,4,5-tetrasubstituted pyrazole derivatives-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of 1,3,4,5-tetrasubstituted pyrazole derivatives

Published:2016-08-22 Issue:9 Volume:71 Page:973-977
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Yahyavi Hoda¹²,Hosseinzadeh Fatemeh²,Karimi Nastaran²,Moghimi Setareh²,Mahdavi Mohammad³,Nadri Hamid⁴,Moradi Alireza⁴,Shafiee Abbas²,Foroumadi Alireza²³

Affiliation:

1. Department of Chemistry, Alzahra University, Tehran, Iran (Islamic Republic of)

2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

3. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of)

4. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran (Islamic Republic of)

Abstract

Abstract We report a solvent-free synthesis of novel 1,3,4,5-tetrasubstituted pyrazoles and investigate their inhibitory activity against soybean 15-lipoxygenase. It was revealed that all synthesized compounds exhibited good activity, and among them, 3-(furan-2-yl)-1,4,5-triphenyl-1H-pyrazole (5j) showed 10 times stronger inhibitory activity in comparison to the reference drug quercetin.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2016-0092/pdf

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