Stability indicating HPLC method for the simultaneous determination of dapagliflozin and saxagliptin in bulk and tablet dosage form-Reference-Cited by-同舟云学术

Stability indicating HPLC method for the simultaneous determination of dapagliflozin and saxagliptin in bulk and tablet dosage form

Published:2018-03-01 Issue:1 Volume:31 Page:39-43
ISSN:2300-6676
Container-title:Current Issues in Pharmacy and Medical Sciences
language:en
Short-container-title:

Author:

Deepan Thiyagarajan¹²,Dhanaraju Magharla Dasaratha²

Affiliation:

1. Research Scholar, Krishna University , Andhra Pradesh, India

2. Research Lab., GIET School of Pharmacy , Chaitanya Knowledge City, Rajahmundry , 533294 Andhra Pradesh, India

Abstract

Abstract A simple, fast, and highly selective RP-HPLC method was developed for the determination of Dapagliflozin (DAP) and Saxagliptin (SAX) in API and tablet dosage form. The separation was done using a Xterra RP18 (4.6×150 mm, 5 μm particle size) column with Acetonitrile: water (60:40). The isocratic elution mode at a flow rate of 1 mL/min, and the analytes were measured at 248 nm. The retention time for DAP and SAX were about 2.091 and 3.249 min, respectively. Calibration curves were found to be linear in the ranges of 100-500 μg/ml for DAP and 50-250 μg/ml for SAX, with correlation coefficients of 0.9998. The detection and quantification values for DAP was 3.0 and 9.98 μg/ml and SAX was 3.02 and 10 μg/ml respectively.

Publisher

Walter de Gruyter GmbH

Subject

Pharmacology,Molecular Biology,General Medicine,Biochemistry

Reference16 articles.

1. 1. https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin

2. 2. https://pubchem.ncbi.nlm.nih.gov/compound/Saxagliptin

3. 3. Mante GV, Gupta KR, Hemke AT. Estimation of Dapagliflozin from its Tablet Formulation by UV-Spectrophotometry. Pharm Methods 2017; 8, 2:102-7.10.5530/phm.2017.8.16

4. 4. Prasad PBN, Satyanaryana K, Krishnamohan G. Development and Validation ofa Method for Simultaneous Determination of Metformin and Saxagliptin in a Formulation by RP-HPLC, American Journal of Analytical Chemistry 2015;6:841-50.

5. 5. Yunoos M, Sankar DG. A validated stability indicating high-performance liquid chromatographic method for simultaneous determination of metformin Hcl and dapagliflozin in bulk drug and tablet dosage form, Asian J Pharm Clin Res. 2015;8:320-6.

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Diode Array Detector Based RP-UPLC Method for Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Metformin;Research Journal of Pharmacy and Technology;2024-03-31

2. A novel HPLC method for the simultaneous determination of empagliflozin and dapagliflozin: Development, validation, robustness testing and greenness assessment;Arhiv za farmaciju;2024

3. A novel stability indicating RP-HPLC method for the simultaneous determination of dapagliflozin and vildagliptin in tablet dosage forms;Annals of Phytomedicine An International Journal;2023-12

4. Development and validation of high‐performance thin layer chromatographic method for concurrent estimation of dapagliflozin and vildagliptin in combined tablet;SEPARATION SCIENCE PLUS;2023-11

5. A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors;BMC Chemistry;2023-07-16