The system’s genetics of depression and its somatic and mental comorbidities

Author:

Kalinichenko Liubov S.1,Kornhuber Johannes1,Müller Christian P.12

Affiliation:

1. Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6 , 91054 Erlangen , Germany

2. Centre for Drug Research, Universiti Sains Malaysia , 11800 Minden , Penang , Malaysia

Abstract

Abstract Depression is a common mood disorder characterised by high comorbidity with other mental and somatic diseases. New studies reveal a shared genetic base for mental core symptoms and somatic comorbidities. Functional analyses showed multiple brain–body pathways involved. This may help considering new therapeutic approaches for depression as a system’s disorder.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

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