Author:
Huang Fengzhen,Yi Jiping,Zhou Tieqiao,Gong Xiaoxiang,Jiang Hong,Yao Xiaoxi
Abstract
AbstractSubarachnoid hemorrhage (SAH) is a common and frequently life-threatening cerebrovascular disease, which is mostly related with a ruptured intracranial aneurysm. Its complications include rebleeding, early brain injury, cerebral vasospasm, delayed cerebral ischemia, chronic hydrocephalus, and also non neurological problems. Non-coding RNAs (ncRNAs), comprising of microRNAs (miRNAs), small interfering RNAs (siRNAs) and long non-coding RNAs (lncRNAs), play an important role in intracranial aneurysms and SAH. Here, we review the non-coding RNAs expression profile and their related mechanisms in intracranial aneurysms and SAH. Moreover, we suggest that these non-coding RNAs function as novel molecular biomarkers to predict intracranial aneurysms and SAH, and may yield new therapies after SAH in the future.
Reference75 articles.
1. MicroRNA/mRNA profiling and regulatory network of intracranial aneurysm;BMC medical genomics,2013
2. Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage;Journal of neurology, neurosurgery, and psychiatry,2011
3. The role of the precursor structure in the biogenesis of microRNA;Cellular and molecular life sciences : CMLS,2011
4. Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy;International journal of nanomedicine,2012
5. Estradiol reduces ferrous citrate complex-induced NOS2 up-regulation in cerebral endothelial cells by interfering the nuclear factor kappa B transactivation through an estrogen receptor beta-mediated pathway;PloS one,2013
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