The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression-Reference-Cited by-同舟云学术

The association of anxiety and other clinical features with CACNA1C rs1006737 in patients with depression

Published:2022-01-01 Issue:1 Volume:13 Page:320-326
ISSN:2081-6936
Container-title:Translational Neuroscience
language:en
Short-container-title:

Author:

Dam Henrik¹,Buch Jens O. D.¹,Nielsen Annelaura B.²,Weikop Pia³,Jørgensen Martin B.¹

Affiliation:

1. Mental Health Center Copenhagen, University Hospital of Copenhagen, Edel Sauntes Alle 10 , 2100 Copenhagen O , Denmark

2. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen , Copenhagen , Denmark

3. Center for Translational Neuroscience, University of Copenhagen , Copenhagen , Denmark

Abstract

Abstract Background The CACNA1C protein is a L-type calcium channel, which influence affective disorders. Purpose The purpose of the present study was to examine the possible association between the different genotypes of rs100677 CACNA1C gene and anxiety and other clinical symptoms in patients with unipolar depression. Patients and controls A total of 754 patients and 708 controls from the Danish Psychiatric Biobank participated. Results A significant correlation was found between anxiety and the A allele. It was further found that patients with the A allele more often were treated with electroconvulsive therapy and patients with the AA phenotype had the highest age. Limitations The only information about controls was their sex and that they were recruited from the blood bank. Two types of inclusion criteria were used. The clinical data were not complete for all patients.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0244/pdf

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