Sila-Pharmaka, 15. Mitt. [1] Synthese und Eigenschaften des Sila-Pridinols / Sila-Drugs, 15th Communication [1] Synthesis and Properties of Sila-Pridinol

Author:

Steiling Lothar1,Wannagat Ulrich1

Affiliation:

1. Institut für Anorganische Chemie der Technischen Universität Braunschweig, Pockelsstraße 4, D-3300 Braunschweig

Abstract

Abstract Synthesis of the silicon analogue VI b of the drug pridinol and of its homologue VI a was achieved via eq. (l-5b) (Scheme 1). The novel compounds IVa-VIb are described in their properties and confirmed in their structures (Tables I-IV). Some preliminary pharma-cological investigations suggest spasmolytical effects of sila-pridinol seeming to be somewhat better than those of pridinol itself.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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