Affiliation:
1. Institut für Anorganische Chemie der Technischen Universität Braunschweig, PockelsstraCe 4, D-3300 Braunschweig
2. Gesellschaft für Biotechnologische Forschung mbH, D-3300 Braunschweig-Stöckheim
3. Institut für Pharmakologie und Toxikologie der Technischen Universität, D-3300 Braunschweig
Abstract
Abstract
Sila-difenidol (6b), a sila-analogue of the drug difenidol (6a), was synthesized according to Scheme 1. 6b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, 1H NMR and mass spectroscopy. 6 b crystallizes orthorhombic P212121 with a = 11.523(1), b = 14.366(4), c = 11.450(1) Å, Z = 4, Dber = 1.14 gcm-3. The structure was refined to R = 0.050 for 1897 reflexions. A strong nearly linear intramolecular O-H···N hydrogen bond of 2.685 Å is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献