Study of Extraction Equilibria in the Reaction of Alkaline Hydrolysis of Activated Amino Acid Esters / Badanie Równowag Ekstrakcji W Reakcji Zasadowej Hydrolizy Aktywowanych Estrów Aminokwasów

Abstract

Abstract Correlation between observed kinetic effects of phase-transfer catalytic reaction of the alkaline hydrolysis of 4-nitrophenyl ester of N-benzyloxycarbonylglycine-4 in the two-phase system chloroform-borate buffer pH = 10 and a content of ionic forms of catalyst was investigated. The phosphonium salts QX (X = Cl¯, Br¯, I¯) shows high catalytic reactivity. Dependence of the reaction kinetics discussed in the framework of the extraction mechanism with a competitive extraction of a nucleophile ОН¯, nucleofuge 4-NO2C6H4O¯ and anion X¯ of the phase-transfer catalyst.