On the Active Principles of the Euphorbiaceae, IXa Ingenane Type Diterpene Esters from Five Euphorbia Species

Author:

Gotta H.1,Adolf W.2,Opferkuch H. J.2,Hecker E.2

Affiliation:

1. Institut für Biochemie, Deutsches Krebsforschungszentrum, D-6900 Heidelberg, FRG

2. Institut für Biochemie, Deutsches Kresforschungszentrum, D-6900 Heidelberg, FRG

Abstract

Investigations of E. antiquorum, E. helioscopia, E. palustris, E. peplus and E. quadrialata for irritant and tumor promoting constituents afforded several new ingenane type diterpene esters derived from the parent alcohols ingenol and 20-deoxyingenol and from the hitherto unknown 20- deoxy-16-hydroxyingenol and 20-deoxy-13.16-dihydroxyingenol. The irritant activities of the natural compounds are reported together with some aspects on structure activity relationships

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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