Molecular epidemiology of human papillomavirus in pregnant women in Burkina Faso

Author:

Kabre Koudpoko Madeleine12,Ouermi Djénéba12,Zohoncon Théodora Mahoukèdè1234,Traore Fatié Porzé Wilfried4,Gnoumou Ouamini Pulchérie De Prisca3,Ouedraogo Rogomenoma Alice12,Yonli Albert Théophane12,Bado Prosper12,Ouedraogo Paul4,Ouedraogo Teega-Wendé Clarisse12,Yelemkoure Tampoula Edwige12,Kuassi-Kpede Punya Akouélé12,Obiri-Yeboah Dorcas5,Ouedraogo Charlemagne Marie Ragnag-Néwendé6,Simpore Jacques1234

Affiliation:

1. Laboratory of Molecular Biology and Genetics (LABIOGENE), Department of Biochemistry and Microbiology, University of Joseph KI-ZERBO, 03 BP 7021 , Ouagadougou 03 , Burkina Faso

2. Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 , Ouagadougou 01 , Burkina Faso

3. Faculty of Medicine, University of Saint Thomas Aquinas, 06 BP 10212 , Ouagadougou 01 , Burkina Faso

4. Saint Camille Hospital of Ouagadougou (HOSCO) , Ouagadougou BP 444 , Burkina Faso

5. Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast , Cape Coast , Ghana

6. University Joseph Ki-Zerbo, UFR/SDS, 03 BP 7021 Ouagadougou 03 , Ouagadougou , Burkina Faso

Abstract

Abstract Introduction Genital human papillomavirus (HPV) infection is widespread among sexually active individuals. Several factors may contribute to increased risk of infection in pregnant women. The objective of this study was to determine the high-risk (HR-HPV) and low-risk (LR-HPV) oncogenic HPV genotypes among pregnant women in Ouagadougou. Methodology In this study, 100 endocervical samples were collected using a sterile swab on the sterile examination glove used during vaginal examination in pregnant women. DNA from each sample was amplified by PCR followed by hybridization using the HPV Direct Flow Chips kit detecting 36 HPV genotypes. Results Twenty-three percent (23%) of pregnant women had HPV infection. Of the 36 genotypes tested, 29 genotypes had been identified with a predominance of HPV 52 (10.34%), HPV 35 (6.89%), and HPV 82 (6.89%) for high risk and HPV 43 (10.34%), HPV 44/55 (6.90%), and HPV 62/81 (6.89%) for low risk. Conclusion HPV is common among pregnant women in Burkina Faso. However, the available vaccines do not cover the frequent genotypes found in this study. HPV could therefore constitute a threat for pregnant women and a risk of infection for the newborn.

Publisher

Walter de Gruyter GmbH

Subject

Cellular and Molecular Neuroscience,General Biochemistry, Genetics and Molecular Biology,General Medicine

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