In vitro Inhibition of Cholinesterases by Carbamates - A Kinetic Study-Reference-Cited by-同舟云学术

In vitro Inhibition of Cholinesterases by Carbamates - A Kinetic Study

Published:2007-04-01 Issue:3-4 Volume:62 Page:305-307
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Komersová Alena¹,Masopustová Markéta²,Komers Karel²,Štěpánková Šárka³,Čegan Alexandr³

Affiliation:

1. Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Na´m. Legií 565, 532 10 Pardubice, Czech Republic

2. Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Nám. Legií 565, 532 10 Pardubice, Czech Republic

3. Department of Biological and Biochemical Sciences, University of Pardubice, Štrossova 239, 530 02 Pardubice, Czech Republic

Abstract

Abstract Kinetics and mechanism of in vitro hydrolyses of acetylcholine and acetylthiocholine by carbamates were studied in a batch reactor at 25 °C, pH 8, and ionic strength of 0.11 m. Every hydrolysis was monitored by 3-4 independent methods. All studied hydrolyses can be described by the model of competitive inhibition with an irreversible step (k3). A table of obtained average values of rate constants and discussion of the resultes are given.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2007-3-422/pdf

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