Microwave-assisted synthesis and biological evaluation of thiazole-substituted dibenzofurans

Author:

Kumar Baba N.H.12,Ashok D.3,Rao Boddu Ananda3,Madderla Sarasija4,Murthy N.Y.S.5

Affiliation:

1. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad 500085, Telangana, India

2. Chemveda Life Sciences India Pvt Ltd., I.D.A. Uppal, Hyderabad 500039, Telangana, India

3. Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad 500007, India

4. Department of Chemistry, Satavahana University, Karimnagar 505001, Telangana, India

5. Department of Chemistry, Anurag Group of Institutions, Hyderabad 501301, Telangana, India

Abstract

AbstractNew thiazole-substituted dibenzofurans 7a–j were synthesized from dibenzofuran derivatives 5a–b and substituted thiosemicarbazones 6a–h under conventional and microwave irradiation conditions. The structures of all products were established on the basis of analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive and Gram-negative strains. Compounds 7b, 7d and 7h are active against Bacillus subtilis (+ve), and compound 7i displays good activity against Pseudomonas aeruginosa (-ve) strain. Compounds 7a–j were also evaluated for their in vitro antimycobacterial activity, and compound 7b shows antimycobacterial activity against Mycobacterium bovis strain.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

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