Abstract
AbstractNew 1-aryl-4-[(aziridine-1-yl)diarylmethyl]-5-methyl-1H-1,2,3-triazole derivatives7a–iwere synthesized by a one-pot reaction of diaryl-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)methanols6a–iderived from 1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxylic acids4a–c. Structures of compounds7a–iwere confirmed by analysis of proton nuclear magnetic resonance (1H NMR) and carbon-13 nuclear magnetic resonance (13C NMR), mass spectrometry (MS) and infrared (IR) data. The structure of compound7fwas studied by X-ray diffraction analysis. The anticancer activities of compounds7a–iagainst human leukemia HL-60 cells and human hepatoma G2 cells were evaluated. Some of the compounds are highly active.
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