Crystal structure and molecular docking studies of 1,2,4,5-tetraaryl substituted imidazoles-Reference-Cited by-同舟云学术

Crystal structure and molecular docking studies of 1,2,4,5-tetraaryl substituted imidazoles

Published:2018-08-28 Issue:4 Volume:24 Page:205-210
ISSN:2191-0197
Container-title:Heterocyclic Communications
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Author:

Sharma Devinder Kumar¹,Jayashree Avvadukkam²,Narayana Badiadka²,Sarojini Balladka Kunhana³,Ravikumar Chandrasekaran⁴,Murugavel Saminathan⁵,Anthal Sumati¹,Kant Rajni¹

Affiliation:

1. X-ray Crystallography Laboratory, Department of Physics, University of Jammu, Jammu Tawi 180006, India

2. Department of Studies in Chemistry, Mangalore University, Mangalagangotri 574199, India

3. Department of Studies in Chemistry-Industrial Chemistry Section, Mangalore University, Mangalagangotri 574199, India

4. Thanthai Periyar, Government Polytechnic College, Vellore, Tamil Nadu, India

5. Thanthai Periyar, Government Institute of Technology, Vellore, Tamil Nadu, India

Abstract

Abstract2-(4-Bromophenyl)-1-(3-chloro-2-methylphenyl)- 4,5-diphenyl-1H-imidazole (1) and 1-(3-chloro-2-methylphenyl)-2-(4-chlorophenyl)-4,5-diphenyl-1H-imidazole (2) were synthesized by one-pot four-component reactions. These compounds crystallize in the monoclinic crystal system with the space group P21/n. The crystal structures were solved by direct methods and refined by a full matrix least squares procedure to a final R value of 0.0572 (1) and 0.0588 (2) for 2748 and 2278 observed reflections, respectively. Molecular docking studies were implemented to understand the inhibitory activity of related compounds against glucosamine 6-phosphate (GlcN-6-P) synthase, the target protein for the antimicrobial agents.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2017-0165/pdf

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