Structure-Dependent Biological Activity of Racemic 1-Substituted 2-0-Hexadecylglycero-3-phosphocholines and Analogues

Abstract

1-substituted 2-O-hexadecylglycero-3-phosphocholines and some structural analogues were tested for their biological activity on two entirely different test systems: human thrombocytes and potato virus X in tobacco plants. Structural prerequisites for a high activity in both systems are the alkyl glyceryl ether structural element, a short-chain substituent in the C-1 position, and the phosphocholine grouping. Accordingly, 1-O-methyl derivative (2) and 1-O-acetyl derivative (5) have the strongest effect on the biological activity of both test systems. The intensity of the effect of the tested compounds does not correlate with membranolytic properties measured by the lytic action on red cells