Feeding and Molt Inhibition by Azadirachtins A, B, and 7-Acetyl-azadirachtin A in Rhodnius prolixus Nymphs

Author:

Garcia Eloi S.1,Azambuja Patricia de2,Forster Hans3,Rembold Heinz3

Affiliation:

1. Department of Biochemistry and Molecular Biology, Department of Entomology, Fundação Oswaldo Cruz, Av Brasil 4365, 21040, Rio de Janiero, Brazil.

2. Department of General Biology, UFF, Niteroi, RJ, Brazil

3. Max-Planck-Institut für Biochemie, D-8033 Martinsried bei München.

Abstract

Abstract The antifeedant and antimolting effects of azadirachtins A and B, and of a synthetic derivative, 7-acetyl-azadirachtin A were examined. Given through a blood meal, the effective dose (ED50) for the antifeedant effect ranged from 25 to 30 μg/ml of blood for the three compounds. ATP, a phagostimulant, also given orally, reversed the antifeedant action of azadirachtin A. The ED50 values for molt inhibition were 0.04, 0.015, and 0.45 (μg/ml of blood for azadirachtins A, B, and 7-acetyl-azadirachtin A, respectively. The mechanisms of feeding and molt inhibitions by azadirachtin A B, and its 7-acetyl-azadirachtin A derivative are discussed.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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