Affiliation:
1. Martin Luther University Halle-Wittenberg , Institute of Physiological Chemistry , Hollystr. 1 , D-06114 Halle , Germany
Abstract
Abstract
The Saccharomyces cerevisiae Gid-complex is a highly evolutionary conserved ubiquitin ligase with at least seven protein subunits. Here, we review our knowledge about the yeast Gid-complex as an important regulator of glucose metabolism, specifically targeting key enzymes of gluconeogenesis for degradation. Furthermore, we summarize existing data about the individual subunits, the topology and possible substrate recognition mechanisms and compare the striking similarities, but also differences, between the yeast complex and its vertebrate counterpart. Present data is summarized to give an overview about cellular processes regulated by the vertebrate GID-complex that range from cell cycle regulation, primary cilia function to the regulation of energy homeostasis. In conclusion, the vertebrate GID-complex evolved as a versatile ubiquitin ligase complex with functions beyond the regulation of glucose metabolism.
Funder
Deutsche Forschungsgemeinschaft
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Cited by
36 articles.
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