Numerical investigation of diagnostic properties of p53-dependent microRNAs-Reference-Cited by-同舟云学术

Numerical investigation of diagnostic properties of p53-dependent microRNAs

Published:2017-01-01 Issue:3 Volume:32 Page:
ISSN:1569-3988
Container-title:Russian Journal of Numerical Analysis and Mathematical Modelling
language:
Short-container-title:

Author:

Voropaeva Olga F.,Senotrusova Sofia D.,Shokin Yurii I.

Abstract

AbstractIn the present paper we propose a mathematical model and study numerically the functioning of the p53 tumors suppressor protein and the direct positive connection of microRNA molecules related to it. The adequacy of the model is confirmed by qualitative concordance of calculation results with the experimental data concerning transactivation of specific p53-dependent microRNAs. Estimates of stability of individual and p53-mediated properties of microRNA as factors in diagnosing cancer and neurodegenerative diseases are given within the framework of the accepted model.

Publisher

Walter de Gruyter GmbH

Subject

Modelling and Simulation,Numerical Analysis

Link

https://www.degruyter.com/document/doi/10.1515/rnam-2017-0018/pdf

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