1. Precision Medicine Unit, Department of Biotechnology, Faculty of Natural Sciences , University of the Western Cape , Bellville , South Africa
2. Department of Family Medicine , Walter Sisulu University , East London , South Africa
3. South African Medical Research Council , Parow , Cape Town , South Africa
4. Division of Medical Physiology, Faculty of Medicine and Health Sciences , Stellenbosch University , Tygerberg , South Africa
5. Department of Family Medicine , Center for Teaching and Learning, Piet Retief Hospital , Mkhondo , Mpumalanga , South Africa