Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart-Reference-Cited by-同舟云学术

Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

Published:2018-06-01 Issue:2 Volume:19 Page:131-139
ISSN:2335-075X
Container-title:Serbian Journal of Experimental and Clinical Research
language:en
Short-container-title:

Author:

Jeremic Nevena¹,Zivkovic Vladimir²,Srejovic Ivan²,Jeremic Jovana³,Petkovic Anica³,Bradic Jovana³,Jakovljevic Vladimir²⁴

Affiliation:

1. Department of Pharmaceutical chemistry, Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia

2. Department of Physiology, Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia

3. Department of Pharmacy, Faculty of Medical Sciences , University of Kragujevac , Kragujevac , Serbia

4. Department of Human Pathology , 1st Moscow State Medical University IM Sechenov , Moscow , Russia

Abstract

Abstract Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO2 −), superoxide anion radicals (O2 −), index of lipid peroxidation (TBARS) and hydrogen peroxide (H2O2) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors. Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism. Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia

Publisher

Centre for Evaluation in Education and Science (CEON/CEES)

Subject

General Medicine

Reference27 articles.

1. 1. Przyklenk, K., & Kloner, R. A. (1998). Ischemic preconditioning: exploring the paradox. Prog Cardiovasc Dis, 40(6), 517-547.10.1016/S0033-0620(98)80002-9

2. 2. Ara, J., Fekete, S., Frank, M., Golden, J. A., Pleasure, D., & Valencia, I. (2011). Hypoxic-preconditioning induces neuroprotection against hypoxia-ischemia in newborn piglet brain. Neurobiol Dis, 43(2), 473-485.10.1016/j.nbd.2011.04.021

3. 3. Cantagrel, S., Krier, C., Ducrocq, S., Bodard, S., Payen, V., Laugier, J., Chalon, S. (2003). Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia. Neurosci Lett, 347(2), 106-110.

4. 4. Altug, S., Demiryurek, A. T., Kane, K. A., & Kanzik, I. (2000). Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts. Br J Pharmacol, 130(1), 125-131.

5. 5. Verma, S., Maitland, A., Weisel, R. D., Li, S. H., Fedak, P. W., Pomroy, N. C., Rao, V. (2002). Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. J Thorac Cardiovasc Surg, 123(6), 1120-1124.