Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid

Published:2017-03-01 Issue:1 Volume:18 Page:13-18
ISSN:2335-075X
Container-title:Serbian Journal of Experimental and Clinical Research
language:en
Short-container-title:

Author:

Tomovic Dusan Lj.¹,Bukonjic Andriana M.¹,Kocovic Aleksandar¹,Nikolic Milos V.¹,Mijajlovic Marina Z.¹,Jevtic Verica V.²,Ratkovic Zoran R.²,Arsenijevic Aleksandar N.¹,Milovanovic Jelena Z.¹,Stojanovic Bojana¹,Trifunovic Srecko R.²,Radic Gordana P.¹

Affiliation:

1. Faculty of Medical Sciences, University of Kragujevac, Serbia

2. Department of Chemistry, Faculty of Science, University of Kragujevac, Serbia

Abstract

Abstract New complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (alkenyl = propenyl-(L1), isobutenyl-(L2)) have been synthesized and characterized by microanalysis, infrared spectra, magnetic measurements, and by NMR spectra. The cytotoxic activity of two newly synthesized precursor S-alkenyl derivatives of thiosalicylic acid were tested using an MTT colorimetric technique on HCT-116 human colon carcinoma cells. The cytotoxic effect of the copper(II)- complexes were higher compared to the cytotoxicity of the corresponding ligand (for concentrations from 31.25 to 250 μM). Copper(II)-complexes showed a slightly lower cytotoxicity compared to cisplatin. Complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (at concentrations from 250 to 1000 μM) had a cytotoxic effect on HCT-116 cells compared to cisplatin.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

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