Regularities of Oxidative Stress Course in Cerebral Stroke

Abstract

Abstract Objective of the article: to improve diagnosis and treatment results of patients with ischaemic and haemorrhagic strokes by means of a comprehensive in-depth review of free radical processes and the defining of patterns of their course under the conditions of stroke. During the study, the authors established the regularities for the course of free radical processes in stroke with the development of oxidative stress and the severity of peroxidelipid component, which increases in proportion to the severity of ischaemic or haemorrhagic stroke with maximum intensity in cases of adverse outcomes. Multi-stage mathematical modelling allowed for the determination of a highly effective formula for early stroke prognosis, which includes only 5 indicators used for estimation at hospitalization: consciousness level, blood glucose level, number of leukocytes in venous blood, antiperoxide activity of plasma and malondialdehyde. It was found that each of these parameters is an independent marker of hospital mortality. The consideration of all these indicators makes it possible to carry out early prognostic diagnostics with 90% probability and to timely correct treatment. We have also established digital boundaries, which are indications for the administration of energy correct therapy, the proper implementation of which has significantly improved the results of hospital treatment.