Eco-friendly synthesis, characterization, and drug-likeness properties of new uracils and their biological evaluation

Abstract

Abstract Several pyridopyrimidine derivatives have been synthesized through different synthetic processes. The different physicochemical factors for their synthesis were also discussed. A comparison between the conventional and microwave-assisted synthesis was conducted by comparing total time of reaction and its yield percentage. Most of the produced uracils were established for their anti-inflammatory, analgesic, and antioxidant activities. Compounds 1 and 3 were demonstrated as the best results against DNA damage, whereas compounds 2a and 2b exhibited an effective anti-inflammatory activity. Moreover, the Lipinski rule parameters were calculated for the synthesized compounds. The results indicated that compounds 1, 2a and 5 have good potential for subsequent development bioactivity.