Mutagenic and carcinogenic structural alerts and their mechanisms of action-Reference-Cited by-同舟云学术

Mutagenic and carcinogenic structural alerts and their mechanisms of action

Published:2016-09-01 Issue:3 Volume:67 Page:169-182
ISSN:0004-1254
Container-title:Archives of Industrial Hygiene and Toxicology
language:en
Short-container-title:

Author:

Plošnik Alja¹,Vračko Marjan¹,Dolenc Marija Sollner²

Affiliation:

1. National Institute of Chemistry Slovenia, Ljubljana, Slovenia

2. Ljubljana University Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Aškerčeva 7, 1000 Ljubljana, Slovenia

Abstract

Abstract Knowing the mutagenic and carcinogenic properties of chemicals is very important for their hazard (and risk) assessment. One of the crucial events that trigger genotoxic and sometimes carcinogenic effects is the forming of adducts between chemical compounds and nucleic acids and histones. This review takes a look at the mechanisms related to specific functional groups (structural alerts or toxicophores) that may trigger genotoxic or epigenetic effects in the cells. We present up-to-date information about defined structural alerts with their mechanisms and the software based on this knowledge (QSAR models and classification schemes).

Publisher

Walter de Gruyter GmbH

Subject

Public Health, Environmental and Occupational Health,Toxicology

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