Affiliation:
1. Lehrstuhl für Physiologie und Biochemie der Pflanzen, Universität Konstanz, D -7750 Konstanz, Bundesrepublik Deutschland
Abstract
Abstract
New 2-phenylpyridazinones, analogs of 4-chloro-5-methylamino-2-phenylpyridazin-3(2H)ones, were assayed for their phytotoxic activity to interfere with plant pigment formation. Six derivatives with - SCF3, - OCF2CHFCF3, - OCHF2, - CN, or - Br in meta position of the phenyl ring exhibited similar or better bleaching activity than the m-CF3 analog (norflurazon). The activity is predominantly determined by positive σ values and by lipophilicity of the substituent. On the basis of 11 analogs, a quantitative structure-activity relationship by a Hansch equation was accomplished with σm and the lipophilicity parameter π as variables.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
6 articles.
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