Chemical Aspects of the Mutagenic Activity of the Ascorbic Acid Autoxidation System-Reference-Cited by-同舟云学术

Chemical Aspects of the Mutagenic Activity of the Ascorbic Acid Autoxidation System

Published:1982-02-01 Issue:1-2 Volume:37 Page:40-45
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Kalus Werner H.¹,Filby William G.²,Münzner Ruth¹

Affiliation:

1. Federal Research Centre for Nutrition, Engesserstr. 20, D-7500 Karlsruhe

2. Institute of Radiochemistry, Nuclear Research Centre, D-7500 Karlsruhe

Abstract

It has been proposed that the mutagenic activity associated with the ascorbic acid autoxidation system may involve hydrogen peroxide and peroxide radicals. We report here that the mutagenic effect may also partially reside in as yet unknown secondary products. The observed mutagenicity of 2,3-diketogulonic acid, one of the main oxidation products, reflects its ability to form hydrogen peroxide.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-1982-1-208/pdf

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1. Formation of guanosine adducts from l-ascorbic acid under oxidative conditions;Bioorganic & Medicinal Chemistry Letters;1997-10

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