Struktur-Wirkungsbeziehungen von Analogen und Homologen von Blepharisma, dem niedermolekularem Konjugationshormon von Blepharisma japonicum / Structure-Activity-Relation of Analogues and Homologues of Blepharismone, the Low-Molecular Conjugation Hormone of Blepharisma japonicum

Abstract

Abstract Some functional derivatives of blepharismone, the low-molecular conjugation hormone of Blepharisma japonicum, were synthesised and tested for their biological activity. The lipophilicity constant of the substituent in 5-position of the aromatic system directly correlates with the conjugation-inducing effect of this substance. Any change in the N-formyl-position leads to compounds less active than blepharismone, non-active or even inhibitory. Blepharismone-related kynurenine derivatives are inhibitors of the gamone activity depending on structural relationship.