Die Wirkung von 9.10-Phenanthrenhydrochinon-bisglycylester auf den Ehrlich-Ascites-Tumor der Maus und das Jensen-Sarkom der Ratte

Abstract

9.10-phenanthrahydroquinone formed by the enzymatic hydrolysis of 9.10-phenanthrahydroquinone-bisglycylester undergoes a redox-cycle in tumor-cells. H2O2 is formed during the autoxidation of the hydroquinone. The amount of H2O2 is especially large in aerobically glycolyzing cells. The cancerostatic action of the hydroquinone-bisglycylester was tested on Ehrlich-Ascites-carcinoma-cells and on Jensen-sarcoma. When Ehrlich-Ascites-cells preincubated with 3.4 to 8.4·10-5 Mol/l Ester for 30 minutes at 37°C are injected into mice, the development of Ascites-tumors is inhibited. Injection of the ester directly into Ascites-tumors has no effect. One of the reasons for this may be the low oxygen content of the Ascites-tumor, which does not permit the redox-cycle to operate. In a part of the cases full regression of Jensen-sarcoma was obtained after injecting 8.2·10-5 Mol/kg Ester 2 - 3 times intravenously every of 2 -3 days.