Affiliation:
1. Campus Clinic Gynecology , Ruhr-University Bochum , Bochum , Germany
Abstract
Abstract
Cerebral palsy, the most common disability in childhood, is a devastating non-progressive ailment of the infants’ brain with lifelong sequelae, e.g., spastic paresis, chronic pain, inability to walk, intellectual disability, behavioral disorders, for which there is no cure at present. CP may develop after pediatric brain damage caused, e.g., by hypoxic-ischemia, periventricular leukomalacia, intracranial hemorrhage, hypoxic-ischemic encephalopathy, trauma, stroke, and infection. About 17 million people worldwide live with cerebral palsy as a result of pediatric brain damage. This reflects both the magnitude of the personal, medical, and socioeconomic global burden of this brain disorder and the overt unmet therapeutic needs of the pediatric population. This review will focus on recent preclinical, clinical, and regulatory developments in cell therapy for infantile cerebral palsy by transplantation of cord blood derived mononuclear cells from bench to bedside. The body of evidence suggests that cord blood cell therapy of cerebral palsy in the autologous setting is feasible, effective, and safe, however, adequately powered phase 3 trials are overdue.
Subject
Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference76 articles.
1. Jensen, A, Berger, R, Garnier, Y, Meier, C. Das kindliche Gehirn schützen, Nervenzellen ersetzen. Rubin 2003;1:26–33.
2. Jensen, A, Vaihinger, HM, Meier, C. Frühkindliche Hirnschäden – Von der Neuroprotektion zur Neuroregeneration mit Nabelschnurstammzellen. Med Klin 2003;98(2 Suppl):S22–6.
3. Jensen, A. Pediatric stroke and cell-based treatment – pivotal role of brain plasticity. J Stem Cell Res Transplant 2019;6:1029. https://doi.org/10.26420/jstemcellrestransplant.2019.1029.
4. Paton, MCB, Finch-Edmondson, M, Fahey, MC, London, J, Badawi, N, Novak, I. Fifteen years of human research using stem cells for cerebral palsy: a review of the research landscape. J Paediatr Child Health 2021;57:295–6. https://doi.org/10.1111/jpc.15329.
5. Hoda, ZAH, Zeldin, AS, Bazzano, ATF, Ratanawongsa, B, Kao, A, Neumeyer, AM, et al.. Cerebral Palsy; 2015. Available from: http://emedicine.medscape.com/article/1179555-overview#showall.
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