Maternal serum midkine level in fetal growth restriction: a case-control study
Author:
Oluklu Deniz1, Beser Dilek Menekse1, Hendem Derya Uyan1, Kara Ozgur1, Yazihan Nuray2, Sahin Dilek3
Affiliation:
1. Department of Obstetrics and Gynecology, Division of Perinatology , Turkish Ministry of Health Ankara City Hospital , Cankaya , Ankara , Turkey 2. Department of Pathophysiology, Internal Medicine , Ankara University Medical School , Cankaya , Ankara , Turkey 3. Department of Obstetrics and Gynecology, Division of Perinatology , Turkish Ministry of Health Ankara City Hospital, University of Health Sciences , Ankara , Turkey
Abstract
Abstract
Objectives
To compare maternal serum midkine (MK) level in pregnant women with idiopathic fetal growth restriction (FGR) and healthy. In addition, we assessed the value of maternal serum MK level in predicting neonatal intensive care unit (NICU) admission.
Methods
A total of 144 pregnant women were included, 72 with idiopathic FGR and 72 healthy in this study. The control group was matched for the mother’s age, parity, gestational age, and pre-pregnancy body mass index (BMI) with the idiopathic FGR group at the time of recruitment into the study and sample collection.
Results
Serum MK level is higher in the idiopathic FGR than the control group (0.24 ng/mL (0.19–0.32) vs. 0.18 ng/mL (0.14–0.23), p<0.001). In addition, we compared the maternal serum MK level of those with and without NICU admission in the FGR group (0.25 ng/mL (0.19–0.37) vs. 0.21 ng/mL (0.18–0.28), p=0.014). We performed ROC curve analysis to serum MK level predicting NICU admission in the FGR group (AUC: 0.668, %95 CI [0.550, 0.785], p=0.014). A sensitivity of 63% and a specificity of 62% for the serum MK level were achieved with a cut-off value of 0.22 for NICU admission.
Conclusions
To the best of our knowledge, this study is the first to compare maternal serum MK level in pregnant women with idiopathic FGR and healthy. We showed that maternal serum MK level was significantly elevated in pregnant women with FGR than healthy.
Publisher
Walter de Gruyter GmbH
Subject
Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference23 articles.
1. Miller, J, Turan, S, Baschat, AA. Fetal growth restriction. Semin Perinatol 2008;32:274–80. https://doi.org/10.1053/j.semperi.2008.04.010. 2. Chen, HY, Chauhan, SP, Ward, TC, Mori, N, Gass, ET, Cisler, RA. Aberrant fetal growth and early, late, and postneonatal mortality: an analysis of Milwaukee births, 1996–2007. Am J Obstet Gynecol 2011;204:261.e1–10. https://doi.org/10.1016/j.ajog.2010.11.040. 3. Zeitlin, J, Ayoubi, ME, Jarreau, PH, Draper, ES, Blondel, B, Künzel, W, et al.. Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort. J Pediatr 2010;157:733–9.e1. https://doi.org/10.1016/j.jpeds.2010.05.002. 4. De Jesus, LC, Pappas, A, Shankaran, S, Li, L, Das, A, Bell, EF, et al.. Outcomes of small for gestational age infants born at <27 weeks’ gestation. J Pediatr 2013;163:55–60.e1–3. https://doi.org/10.1016/j.jpeds.2012.12.097. 5. Naemi, M, Farahani, Z, Norooznezhad, AH, Khodarahmi, R, Hantoushzadeh, S, Ahangari, R, et al.. Possible potentials of curcumin for pregnancies complicated by intra-uterine growth restriction: role of inflammation, angiogenesis, and oxidative stress. Heliyon 2021;7:e08034. https://doi.org/10.1016/j.heliyon.2021.e08034.
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