Affiliation:
1. 1Aix Marseille Université, Centrale Marseille, CNRS iSm2 UMR 7313, 13397, Marseille, France
Abstract
AbstractWe present recent advances in the understanding of the reduction of optically pure hydroxyalkylphosphinates and phosphine oxides, which represent key intermediates for the preparation of P-stereogenic ligands. Their reduction leads to P-chiral phosphinites and phosphines, respectively, and occurs stereospecifically with inversion of configuration using BH3·THF, which plays three roles: activating, reducing and protecting agent. The formation of by-products as hydroxyalkyl secondary phosphine–boranes has also been studied.
Subject
General Chemical Engineering,General Chemistry
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