Zur Biosynthese der Penicilline: Bildung von 5-(2-Aminoadipyl)-cysteinyl-valin in Extrakten von Penicillium chrysogenum / Formation of 5-(2-Aminoadipyl)-cysteinyl-valin by Extracts of Penicillium chrysogenum

Abstract

Mycel-extracts of P. chrysogenum catalyse the formation of 5- (2-aminoadipoyl) -cysteinyl-valin out of its aminoacid components. For the synthetical preparation of this compound the solid-phase method is particularly suited. The synthesis can be carried out even with very small quantities of substance and thereby allows the preparation of radioactive labelled L-5- (2-aminoadipoyl) -L-cysteinyl-L-valin of relatively high specific activity.